Classic Classic Quiz MD4001 MSA drugs by Elpip Elpip 3 played - 12 yrs ago Pharamacology revision QUIZ 25 QUESTIONS expert 1 Carbamazepine Acts on CNS to stimulate aminergic transmission (dopamine - euphoria, noradrenaline - locomotor, serotonin - anorexia)Mechanism unknownUses dependent block of Na+ channelsInhibits cAMP/cGMP phosphodiesterases blocking purine receptors 2 Felbamate UnkownInhibits GABA transaminaseActs on CNS to stimulate aminergic transmission (dopamine - euphoria, noradrenaline - locomotor, serotonin - anorexia)Influences/alters 5-HT (serotonin) transmission of the CNS 3 Mescaline Influences/alters 5-HT (serotonin) transmission of the CNSUses dependent block of Na+ channelsBlocks GABAa receptors in brain (not spinal cord)Uses dependent block of Na+ channels 4 Ecstasy Mechanism unknownInfluences/alters 5-HT (serotonin) transmission of the CNSInhibits cAMP/cGMP phosphodiesterasesShort acting respiratory stimulant 5 Methylxanthines Inhibit cAMP/cGMP phosphodiesterasesInfluence/alter 5-HT (serotonin) transmission of the CNSAct on CNS to stimulate aminergic transmission (dopamine - euphoria, noradrenaline - locomotor, serotonin - anorexia)Block GABAa receptors in brain (not spinal cord) 6 Nikethamide Influences/alters 5-HT (serotonin) transmission of the CNSActs on CNS to stimulate aminergic transmission (dopamine - euphoria, noradrenaline - locomotor, serotonin - anorexia)UnkownInhibits cAMP/cGMP phosphodiesterases blocking purine receptors 7 Amphetamine Short acting respiratory stimulantMechanism unknownActs on CNS to stimulate aminergic transmission (dopamine, noradrenaline, serotonin)Blocks GABAa receptors in brain (not spinal cord) 8 Fenfluramine Blocks GABAa receptors in brain (not spinal cord)GABA-uptake inhibitorUses dependent block of Na+ channelsActs on CNS to stimulate aminergic trasmission (dopamine, noradrenaline, serotonin). May have selective action on 5-HT - causes anorexia without stimu 9 Valproate Inhibits GABA transaminaseNot clear. Increase in GABA content of the brain. Weak inhibitor of GABA transaminase. Some effect of sodium channelsUses dependent block of Na+ channelsInfluences/alters 5-HT (serotonin) transmission of the CNS 10 Vigabatrin Mechanism unknown (simple analogue of GABA)Inhibits cAMP/cGMP phosphodiesterases blocking purine receptorsInhibits GABA transaminaseGABA-uptake inhibitor 11 Ethosuximide Blocks T-type calcium channelsMechanism unknown (analogue of piracetam)GABA-uptake inhibitorInhibits NA uptake 1 into adrenergic nerve terminals 12 Diazepam Uses dependent block of Na+ channelsSelective 5-HT uptake inhibitorBlocks delta-receptor and glutamate NMDA-receptor channel. And other neurotransmitter systemsBenzodiazepine - Enhances GABAergic transmission - GABA1 agonist 13 Doxapram Blocks GABAa receptor evoked chloride ion entry. (like GABA receptor agonist but not because acts on a site different to the GABA binding site to moduInfluences/alters 5-HT (serotonin) transmission of the CNSShort acting respiratory stimulantBlocks glycine receptors - main inhibitory transmitter acting on motorneurons. Works on spinal cord. Causes violent extensor spasms, triggered by mino 14 Buspirone 5-HT1A receptor agonistInhibits GABA transaminaseBlocks Na+ channelsBlocking T-type calcium channels 15 Cocaine Influences/alters 5-HT (serotonin) transmission of the CNSInhibits NA uptake 1 into adrenergic nerve terminalsInhibits cAMP/cGMP phosphodiesterasesActs on CNS to stimulate aminergic transmission (dopamine, noradrenaline, serotonin). May have selective action on 5-HT -causes anorexia without stimu 16 Gabapentin Uses dependent block of Na+ channelsMechanism unknown (simple analogue of GABA)GABA-uptake inhibitorInfluences/alters 5-HT (serotonin) transmission of the CNS 17 Levetiracetam Blocks glycine receptors - main inhibitory transmitter acting on motorneurons. Works on spinal cord. Causes violent extensor spasms, triggered by minoBlocks GABAa receptors in brain (not spinal cord)Mechanism unknown (analogue of piracetam)GABA-uptake inhibitor 18 Topiramate Blocks Na+ channelsBlocks GABAa receptor evoked chloride ion entry. (like GABA receptor agonist but not because acts on a site different to the GABA binding site to moduMechanism unknown (analogue of piracetam)Blocks glycine receptors - main inhibitory transmitter acting on motorneurons. Works on spinal cord. Causes violent extensor spasms, triggered by mino 19 Picrotoxin Blocks GABAa receptors in brain (not spinal cord)GABA-uptake inhibitorBlocks GABAa receptor evoked chloride ion entry. (like GABA receptor agonist but not because acts on a site different to the GABA binding site to moduBlocks Na+ channels 20 Strychnine Blocks glycine receptors - main inhibitory transmitter acting on motorneurons. Works on spinal cord. Causes violent extensor spasms, triggered by minoBlocks Na+ channelsUnkownMechanism unknown (analogue of piracetam) 21 Lamotrigine Mechanism unknown (analogue of piracetam)GABA-uptake inhibitorBlocks Na+ channelsBlocks GABAa receptors in brain (not spinal cord) 22 Tiagabine GABA-uptake inhibitorBlocks Na+ channelsBlocks GABAa receptors in brain (not spinal cord)Blocks GABAa receptors in brain (not sActs on CNS to stimulate aminergic transmission (dopamine, noradrenaline, serotonin). May have selectipinal cord 23 Zonisamide UnkownActs on CNS to stimulate aminergic transmission (dopamine, noradrenaline, serotonin). May have selective action on 5-HT -causes anorexia without stimuBlocks Na+ channelsUse dependent block of Na+ channels 24 Bicuculline Uses dependent block of Na+ channelsBlocks GABAa receptors in brain (not spinal cord)UnkownActs on CNS to stimulate aminergic transmission (dopamine, noradrenaline, serotonin). May have selective action on 5-HT -causes anorexia without stimu 25 Leptazol Mechanism unknown (analogue of piracetam)UnkownActs on CNS to stimulate aminergic trasmission (dopmaine, noradrenaline, serotonin). May have selective action on 5-HT - causes anorexia without stimuGABA-uptake inhibitor A mistake in this Quiz ? Contact the author Commentaires
