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Cardiology : Tropomyosin  

created by tommymoran on 4 Feb 14, enabled by Lou
Hard level (21% of success)    26 questions - 2 players
A proteinate quiz
 
1
Troponin I is...
   
   
   
   
2
A cross bridge is...
   
   
   
   
3
The conformation shift in the adjacent troponin complex due to a tropomyosin shift from calcium binding is termed...
   
   
   
   
4
What is the chance that cross-bridging will induce the formation of another forming...
   
   
   
   
5
What is the limiting factor in a functioning heart...
   
   
   
   
6
What is the "blocked-state? "
   
   
   
   
7
Progression to the closed-state after Ca+ binding to troponin-C is...
   
   
   
   
8
The closed-state (weakly bound state)'s interaction is analogous to...
   
   
   
   
9
In a disease heart, the contraction may fail because...
   
   
   
   
10
ATP propels the myosin head forward from the strong-state (10-15nm), and may...
   
   
   
   
11
The inefficiency of contracting from the weak state is...
   
   
   
   
12
In regulating myofilament, what increases cycling rate?
   
   
   
   
13
What conformational change specifically allows for cycling to increase?
   
   
   
   
14
What is the lifetime risk of heart failure?
   
   
   
   
15
What is systolic heart failure?
   
   
   
   
16
Increasing HR to compensate for poor contractility is...
   
   
   
   
17
Calcium sensitizers...
   
   
   
   
18
Pimobendan is...
   
   
   
   
19
Omecativ Mecarbil is a myosin activator that...
   
   
   
   
20
Fractional shortening...
   
   
   
   
21
What is the largest protein in humans?
   
   
   
   
22
What is the function of titin?
   
   
   
   
23
PKA and PKG phosphorylate titin to...
   
   
   
   
24
PKC may be involved in a diseased state because...
   
   
   
   
25
B-adrenergic receptor can't be targeted in-face of stiffened titin because it is often down-regulated in heart failure. What is a viable downstream target of PKA or PKG?
   
   
   
   
26
What drug helps to increase titin phosphorylation, and decrease titin stiffness, in experiments on dogs?
   
   
   
   
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All comments (1)
0    0    1    0   
Great how am i going to get it all correct


11 December 15