Quiz Cardiology : Calcium Removal

medium

Question 1 / 11

Which of the following is responsible for the majority of calcium clearance from the cytoplasm of ventricular myocytes?

Sarcolemma Ca ATPase

Na /Ca exchanger

Sarcoplasmic Endoplasmic Reticulum Ca ATPase

They're equally responsible

medium

Question 2 / 11

What is the primary function of the Ca uniporter in mitochondria in ventricular myocytes?

Reduce intracellular Ca to allow muscle relaxation

Increase ATP production via glycoylsis to sustain energy expenditure of active ion-pumps

Facilitate diffusion of oxygen molecules across the mitochondrial membrane

B and C

medium

Question 3 / 11

2 Cytoplasmic Ca ions cooperatively bind to the Sarcolemmal Ca ATPase to expose what residue for ATP binding?

Glutamate

Glutamic Acid

Aspartate

Aspartatic Acid

hard

Question 4 / 11

Sarcolemmal Ca ATPase may interact with NOSynthases in caveolae to...

Reduce local Ca levels, reducing NOS synthesis, limiting inotropy and cell contractility

Reduce local Ca levels, increasing NOS synthesis, increasing inotropy and cell contractility

Reduce local Ca levels, increasing NOS synthesis, limiting inotropy and cell contractility

Reduce local Ca levels, reducing NOS synthesis, increasing inotropy and cell contractility

expert

Question 5 / 11

Under what circumstance(s) will the NCX exchange 4Na+ for a Ca instead 3Na ?

Extracellular Alkalosis

Extracellular Acidosis

Exchanger is in Rod Cells

B and C

medium

Question 6 / 11

At Em below -50mV, the NCX will pump Na out of the sarcolemma and Ca in. What "mode" is the exchanger said to be in?

Forward

Reverse

Right

Left

medium

Question 7 / 11

In heart failure, SERCA levels are typically...

Increased

Decreased

Constant

Irrelevant

hard

Question 8 / 11

One treatment for heart failure with reduced levels of SERCA is to...

Transfect SERCA2a genes via adenovirus into myocardium

Treat heart with digoxin. Increased calcium levels will signal SERCA transcription.

Percutaneously inject SERCA formulation into myocardium

A and B

hard

Question 9 / 11

What is the result of Phospholamban's interaction with SERCA?

Increased rate of Ca sparks

Increased Ca efflux from SR

Reduced uptake of cytosolic Ca into SR

A and C

medium

Question 10 / 11

How does mutant PLB interfere with the regulation of wild-type PLB?

It will irreversibly bind and inactivate PKA, thus preventing the phosphorylating and inhibition of wild-type PLB

It will bind to RyR, and reduce intracellular Ca levels

It has no effect on wild-type PLB regulation

A and B

hard

Question 11 / 11

How does phospholamdan contribute to CPVT?

PKA phosphorylates SERCA, which will activate phospholamdan to bind RyR

PKA will phosphorylate it, dissociating it from SERCA and overloading the SR.

Phospholamdan is fat and useless

A and B and C

A mistake in this Quiz ? Contact the author

Quiz Cardiology : Calcium Removal

Which of the following is responsible for the majority of calcium clearance from the cytoplasm of ventricular myocytes?

What is the primary function of the Ca uniporter in mitochondria in ventricular myocytes?

2 Cytoplasmic Ca ions cooperatively bind to the Sarcolemmal Ca ATPase to expose what residue for ATP binding?

Sarcolemmal Ca ATPase may interact with NOSynthases in caveolae to...

Under what circumstance(s) will the NCX exchange 4Na+ for a Ca instead 3Na ?

At Em below -50mV, the NCX will pump Na out of the sarcolemma and Ca in. What "mode" is the exchanger said to be in?

In heart failure, SERCA levels are typically...

One treatment for heart failure with reduced levels of SERCA is to...

What is the result of Phospholamban's interaction with SERCA?

How does mutant PLB interfere with the regulation of wild-type PLB?

How does phospholamdan contribute to CPVT?

Latest quizzes & tests

Mobile & social networks

Professionals

About us