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Cardiology : Action Potentials  

created by tommymoran on 4 Feb 14, enabled by Lou
Hard level (41% of success)    30 questions - 1 092 players
Prep for First Cardiology Midterm
 
1
What is the correct pathway for the heart's conducting system?
   
   
   
   
2
The Sinoatrial (SA) Node is...
   
   
   
   
3
The following is an action potential representative of what class of cells?
   
   
   
   
4
Which phase in the graph below constitutes the "pacemaker potential? "
   
   
   
   
5
What is the resting potential of an SA Nodal cell?
   
   
   
   
6
The action potential in SA Nodal cells is primarily driven by...
   
   
   
   
7
The slow depolarization apparent in phase 4 is primarily due to. .
   
   
   
   
8
What is the function of T-type Ca++ channels?
   
   
   
   
9
Funny currents persist...
   
   
   
   
10
What primarily causes the repolarization in Phase 3?
   
   
   
   
11
What would be one result of hypokalemia in SA nodal cells?
   
   
   
   
12
What is the intrinsic automaticity of the SA node?
   
   
   
   
13
What type of receptor helps to directly control heart rate?
   
   
   
   
14
ß-adrenergic receptors associate with G-proteins. Upon ligand binding, which subunit will bind to and activate adenylyl cyclase?
   
   
   
   
15
Activated adenylyl cyclase cleaves ATP in cAMP, resulting in what?
Activated adenylyl cyclase cleaves ATP in cAMP, resulting in what?
   
   
   
   
16
Cholinergic receptors are associated with a G-protein constituted by the inhibitory alpha-(i)-subunit. Upon decreased cAMP levels, what important kinase activity is deterred?
   
   
   
   
17
What ß-gamma G-protein subunit interaction may counteract the funny current?
   
   
   
   
18
What is the function of the AV node?
   
   
   
   
19
Which has the faster intrinsic automaticity (rate of cycle)?
   
   
   
   
20
What is the function of the delayed action potential in the AV node, compare to that of a Purkinje Fibre, illustrated below?
   
   
   
   
21
What characteristic of the AV Node and AV bundle result in the slower generation of action potential compared to Purkinje Fibres?
   
   
   
   
22
Connexins, intercellular pores, allow the exchange of Na+ ions between cells. What characteristic would you expect of Connexins of the SA and AV nodes compared to Purkinje Fibres?
   
   
   
   
23
What allows the ventricles to contract as a syncitium?
   
   
   
   
24
What ion exchange predominantly drives depolarization in Purkinje Fibres and myocytes?
   
   
   
   
25
Connexin 40 is important for?
   
   
   
   
26
What is atrial fibrillation
   
   
   
   
27
What are possible side-effects of anti-arrhythmic drugs, such as Amiodarone (pacerone)?
   
   
   
   
28
Should medical management with anti-arrhythmic drugs be ineffective, what is an appropriate follow-up procedure?
   
   
   
   
29
What is sick sinus syndrome?
   
   
   
   
30
Why is Tbx18 transfection a potentially attractive treatment for Atrial Fibrillation?
   
   
   
   
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